Girgis N I, Farid Z, Kilpatrick M E, Podgore J K, Sultan Y
U.S. Naval Medical Research Unit No. 3, Cairo, Egypt.
Drugs Exp Clin Res. 1992;18(5):197-9.
Fifty-seven patients, twenty-six males and thirty-one females, aged 6 to 50 years (mean 12.6 years) with proven Salmonella typhi or S. paratyphi A septicaemia, were treated in an open randomized parallel study with either aztreonam or chloramphenicol. Aztreonam was given intramuscularly at a level of 50 to 80 mg/kg body weight per dose every 8 h for 7 days to thirty patients. Chloramphenicol was given orally in a dose of 50 to 70 mg/kg body weight every 6 h for 12 days to twenty-seven patients. All patients responded rapidly to treatment, becoming afebrile and asymptomatic within 5.5 to 6.4 days. Only one patient on aztreonam relapsed following treatment, whereas three patients relapsed after chloramphenicol treatment. There were no serious side effects with either drug.
57例年龄在6至50岁（平均12.6岁），确诊为伤寒沙门菌或甲型副伤寒沙门菌败血症的患者，其中男性26例，女性31例，在一项开放性随机平行研究中接受了氨曲南或氯霉素治疗。30例患者接受氨曲南治疗，每8小时肌肉注射一次，剂量为50至80mg/kg体重，共7天。27例患者接受氯霉素治疗，口服剂量为每6小时50至70mg/kg体重，共12天。所有患者对治疗反应迅速，在5.5至6.4天内退热且无症状。接受氨曲南治疗的患者中只有1例在治疗后复发，而接受氯霉素治疗的有3例复发。两种药物均未出现严重副作用。
