Girgis N I, Kilpatrick M E, Farid Z, Mikhail I A, Bishay E
US Naval Medical Research Unit No. 3, Cairo, Egypt.
Drugs Exp Clin Res. 1990;16(12):607-9.
Fifty-five patients with culture-proven Salmonella typhi and paratyphi enteric fever were assigned to one of two therapeutic regimens. Group I received ceftriaxone 60-80 mg/kg/day intramuscularly for 5-7 days, those in group II received chloramphenicol 50-80 mg/kg/day orally in 4 divided doses for 12-14 days. both groups were comparable as regards age, sex, severity and duration of symptoms prior to admission. A significant reduction in the mean number of days taken for patients to become afebrile, disappearance of clinical signs and symptoms, duration of therapy and hospital stay were observed in patients receiving ceftriaxone as compared to those receiving chloramphenicol. None of the patients receiving ceftriaxone relapsed, while three patients receiving chloramphenicol relapsed. No major reactions were seen with either drug.
55例经培养证实为伤寒沙门菌和副伤寒沙门菌引起肠热症的患者被分配到两种治疗方案之一。第一组患者接受头孢曲松，剂量为60 - 80mg/kg/天，肌肉注射，持续5 - 7天；第二组患者接受氯霉素，剂量为50 - 80mg/kg/天，口服，分4次给药，持续12 - 14天。两组患者在年龄、性别、入院前症状的严重程度和持续时间方面具有可比性。与接受氯霉素治疗的患者相比，接受头孢曲松治疗的患者在退热所需平均天数、临床体征和症状消失、治疗持续时间以及住院时间方面均有显著减少。接受头孢曲松治疗的患者无一复发，而接受氯霉素治疗的有3例复发。两种药物均未观察到严重不良反应。
