Yokota J, Imai H, Seki K, Ninomiya C, Mizuno Y
Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan.
Eur Neurol. 1992;32(6):354-8. doi: 10.1159/000116860.
We report a 67-year-old female with orthostatic and voice tremor. Her orthostatic tremor mainly affected her lower extremities, alternating between antagonist muscle groups at a frequency of 4.4-4.8 Hz. The voice tremor ranged between 4.8 and 8.8 Hz. In this case, the frequency of voice tremor was same as that of orthostatic tremor, suggesting a common origin from a tremor-generating mechanism. These tremors were diagnosed as 'forme fruste' of the essential tremor, not the incipient stage of Parkinson's disease. Medications including clonazepam, perphenazine, Dopa and trihexyphenidyl hydrochloride had no effect on both the orthostatic and voice tremors, but propranolol was somewhat beneficial on voice tremor.
我们报告了一名67岁患有体位性和声音震颤的女性。她的体位性震颤主要影响下肢，拮抗肌群以4.4 - 4.8赫兹的频率交替出现。声音震颤频率在4.8至8.8赫兹之间。在这种情况下，声音震颤的频率与体位性震颤相同，提示它们源于共同的震颤产生机制。这些震颤被诊断为特发性震颤的“顿挫型”，而非帕金森病的早期阶段。包括氯硝西泮、奋乃静、多巴和盐酸苯海索在内的药物对体位性和声音震颤均无效果，但普萘洛尔对声音震颤有一定益处。
