Carnevali O, Mosconi G, Yamamoto K, Kobayashi T, Kikuyama S, Polzonetti-Magni A M
Department of Biology (MCA) University of Camerino, Italy.
Gen Comp Endocrinol. 1992 Dec;88(3):406-14. doi: 10.1016/0016-6480(92)90235-c.
Estradiol 17-beta is known to induce hepatic synthesis and secretion of vitellogenin in all species studied and in Rana esculenta, previous experiments demonstrated the involvement of pituitary in these processes; indeed, in addition to estradiol 17-beta, homologous pituitary homogenate directly stimulated male and female liver to produce vitellogenin in tissue cultures. Therefore, the effect of ovine growth hormone (o-GH) and Rana catesbeiana growth hormone (f-GH) on hepatic vitellogenin synthesis was investigated. In the present in vitro experiments, both o-GH and f-GH positively stimulated vitellogenin synthesis, in female and male liver, in a dose-related fashion. No significant differences were found in VTG levels induced by o-GH and f-GH. The GH stimulatory effects, found during the different phases of the reproductive cycle, displayed different trends related to season and sex.
已知17-β雌二醇可诱导所有已研究物种肝脏合成并分泌卵黄蛋白原，在食用蛙中，先前的实验表明垂体参与了这些过程；实际上，除了17-β雌二醇外，同源垂体匀浆在组织培养中可直接刺激雄性和雌性肝脏产生卵黄蛋白原。因此，研究了绵羊生长激素（o-GH）和牛蛙生长激素（f-GH）对肝脏卵黄蛋白原合成的影响。在目前的体外实验中，o-GH和f-GH均以剂量相关的方式对雌性和雄性肝脏中的卵黄蛋白原合成产生正向刺激作用。o-GH和f-GH诱导的卵黄蛋白原水平未发现显著差异。在生殖周期的不同阶段发现的生长激素刺激作用，呈现出与季节和性别相关的不同趋势。
