近期发病的1型糖尿病中的CD11B淋巴细胞。
CD11B lymphocytes in type 1 diabetes mellitus of recent onset.
作者信息
Bizzarro A, De Bellis A, Amoresano Paglionico V, Auletta M, Gattoni A, Altucci P, Iacono G
机构信息
Cattedra di Patologia Speciale Medica e Metodologia Clinica 3, Naples, Italy.
出版信息
Horm Metab Res Suppl. 1992;26:121-2.
To evaluate the behaviour of CD8+ cells (suppressor/cytotoxic T lymphocytes) and CD8+Leu15+ cells (CD11B, suppressor T lymphocytes) in type 1 diabetes mellitus, 27 newly diagnosed diabetic patients and 47 normal controls were studied. CD8 cells were significantly increased in 6 patients, decreased in 9 and unchanged in 12. In all diabetic patients was present a lack of CD8+ Leu15+ cells. These results show that in newly diagnosed type 1 diabetes mellitus, suppressor T lymphocytes are reduced independently from the number of CD8 cells.
为评估1型糖尿病中CD8+细胞（抑制性/细胞毒性T淋巴细胞）和CD8+Leu15+细胞（CD11B，抑制性T淋巴细胞）的行为，对27例新诊断的糖尿病患者和47例正常对照进行了研究。6例患者的CD8细胞显著增加，9例减少，12例无变化。所有糖尿病患者均缺乏CD8+Leu15+细胞。这些结果表明，在新诊断的1型糖尿病中，抑制性T淋巴细胞减少，且与CD8细胞数量无关。
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