BB/W大鼠中表型细胞毒性抑制性T淋巴细胞缺乏
Deficiency of phenotypic cytotoxic-suppressor T lymphocytes in the BB/W rat.
作者信息
Woda B A, Like A A, Padden C, McFadden M L
出版信息
J Immunol. 1986 Feb 1;136(3):856-9.
The BB/W rat is currently the best model of type I (insulin dependent diabetes). Even though this rat develops an autoimmune disease, they are immune deficient. In this study we have demonstrated the almost complete absence of the OX 8+, OX 19+ T cytotoxic/suppressor population in diabetes prone and acute diabetic rats. This population is present in the diabetes resistant W line. The diabetes prone and acute diabetic rats have a relative increase in OX 8+, OX 19- natural killer (NK) cells. Our data suggests that virtually all OX 8+ cells in diabetes prone and acute diabetic animals are phenotypic NK cells.
BB/W大鼠是目前I型（胰岛素依赖型糖尿病）的最佳模型。尽管这种大鼠会发生自身免疫性疾病，但它们存在免疫缺陷。在本研究中，我们已证实在糖尿病易感性大鼠和急性糖尿病大鼠中，几乎完全不存在OX 8+、OX 19+细胞毒性/抑制性T细胞群体。而在抗糖尿病的W系大鼠中存在该细胞群体。糖尿病易感性大鼠和急性糖尿病大鼠的OX 8+、OX 19-自然杀伤（NK）细胞相对增加。我们的数据表明，糖尿病易感性大鼠和急性糖尿病动物中几乎所有的OX 8+细胞都是表型NK细胞。
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