氨基甲酸乙酯对小鼠肺炎病毒感染严重程度的增强作用。
The enhancing effect of urethane on the severity of infection with pneumonia virus of mice.
作者信息
MIRICK G S, SMITH J M, LEFTWICH C I, LEFTWICH W B
出版信息
J Exp Med. 1952 Feb;95(2):147-60. doi: 10.1084/jem.95.2.147.
Abstract
Urethane, given parenterally or orally to mice, increased the severity of PVM infection. Not only were the lesions more extensive but mice could be infected with smaller inocula of virus and the multiplication of virus in the lung was enhanced. There was atrophy of lymphoid tissues but no suppression was noted of antibody formation. No relation could be found between PVM infection and the development of pulmonary adenomas in mice.
摘要
给小鼠经胃肠外途径或口服氨基甲酸乙酯，会加重肺病毒感染（PVM）的严重程度。不仅病变范围更广，而且小鼠能够被更小剂量的病毒接种物感染，并且病毒在肺中的增殖也会增强。存在淋巴组织萎缩，但未观察到抗体形成受到抑制。在小鼠的肺病毒感染与肺腺瘤的发生之间未发现关联。
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