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Determination of cocaethylene, cocaine and their metabolites in rat serum microsamples by high-performance liquid chromatography, and its application to pharmacokinetic studies in rodents.

作者信息

Lau C E

机构信息

Department of Psychology, Rutgers University, New Brunswick, NJ 08903.

出版信息

J Chromatogr. 1992 Nov 6;582(1-2):167-72. doi: 10.1016/0378-4347(92)80315-h.

DOI:10.1016/0378-4347(92)80315-h
PMID:1491036
Abstract

A single-solvent extraction step high-performance liquid chromatographic method is described for quantitating cocaethylene in rat serum microsamples (50 microliters), a substance formed in vivo when cocaine and ethanol are present concurrently. The separation used a 2 mm I.D. reversed-phase Nova-Pak C18 column with a mobile phase of acetonitrile-phosphate buffer containing an ion-pairing reagent. With an ultraviolet detector operated at 230 nm, a linear response was observed from 0.05 to 2.0 micrograms/ml with a detection limit of 5 ng/ml for cocaethylene, cocaine and norcocaine. The method showed a longer half-life for cocaethylene than for cocaine in rat.

摘要

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