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[一名4个月大男孩患纵隔神经母细胞瘤并伴有漏斗胸的罕见病例——一份手术报告]

[A rare case of mediastinal neuroblastoma with pectus excavatum in a 4-month-old boy--a surgical report].

作者信息

Yoh T, Ohnuki T, Ishikura T, Kei J, Obara T, Nitta S

机构信息

Department of Surgery I, Tokyo Women's Medical College, Japan.

出版信息

Nihon Kyobu Geka Gakkai Zasshi. 1992 Dec;40(12):2227-31.

PMID:1491204
Abstract

Screening of neuroblastoma is commonly performed on 6-month-old infants; therefore, its discovery in children younger than that age is extremely rare. However, a 4-month-old boy with pectus excavatum was found to also have mediastinal neuroblastoma after close examination. This 7 kg child had no apparent symptoms, yet revealed an egg-sized shadow along the right atrium in the chest X-ray film, and along the right side of the vertebrae on CT. Due to the increase in the size of the tumor after two months of observation, we suspected malignant neurogenic tumor and performed a thoracotomy. With a right posterolateral thoracotomy we removed the dark-brown, elastic tumor measuring 6 x 4 x 3 cm and located along the right side of the vertebrae from III through VIII ribs. The origin was the thoracic sympathicus and the pathological diagnosis of the tumor was neuroblastoma with rosset formation. After conducting a post-operative chemotherapy (Jame's protocol), no evidence of recurrence was observed at 33 months after surgical treatment. We summarized the previously reported seven surgically treated cases of Stage I mediastinal neuroblastoma at less than 12 months of age. Among the 2500 pectus excavatum surgeries that have been held at our department, non has been found to have mediastinal neuroblastoma.

摘要

神经母细胞瘤筛查通常在6个月大的婴儿中进行;因此,在该年龄以下儿童中发现极为罕见。然而,一名患有漏斗胸的4个月大男孩在仔细检查后被发现同时患有纵隔神经母细胞瘤。这名7公斤重的儿童没有明显症状,但胸部X光片显示右心房沿线有一个鸡蛋大小的阴影,CT显示椎体右侧也有阴影。经过两个月的观察,由于肿瘤大小增加,我们怀疑是恶性神经源性肿瘤并进行了开胸手术。通过右后外侧开胸手术,我们切除了一个深褐色、质地坚韧的肿瘤,大小为6×4×3厘米,位于第三至第八肋骨椎体右侧。肿瘤起源于胸交感神经,病理诊断为伴有菊形团形成的神经母细胞瘤。在进行术后化疗(詹姆斯方案)后,手术治疗33个月后未观察到复发迹象。我们总结了之前报道的7例12个月以下接受手术治疗的I期纵隔神经母细胞瘤病例。在我们科室进行的2500例漏斗胸手术中,未发现有纵隔神经母细胞瘤病例。

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