Fronza G, Mele A, Redenti E, Ventura P
CNR-Centro per lo Studio delle Sostanze Organiche Naturali, c/o Chemistry Department, Milano, Italy.
J Pharm Sci. 1992 Dec;81(12):1162-5. doi: 10.1002/jps.2600811206.
Proton nuclear magnetic resonance spectroscopy showed that piroxicam sodium salt forms an inclusion complex with beta-cyclodextrin in aqueous solution. The 1:1 stoichiometry of the complex was determined by the continuous variation method. Significant nuclear Overhauser effects were observed between the inner protons of beta-cyclodextrin and protons of both the aromatic rings of piroxicam sodium salt, a result indicating that two isomeric 1:1 complexes must be present in solution within the range of concentrations investigated. The overall association constant was 113 M at 298 K. At concentrations less than 1.0 x 10(-3) M, the complex is completely dissociated.
质子核磁共振光谱表明，吡罗昔康钠盐在水溶液中与β-环糊精形成包合物。通过连续变化法确定了该配合物的化学计量比为1:1。在β-环糊精的内质子与吡罗昔康钠盐两个芳环的质子之间观察到显著的核Overhauser效应，这一结果表明在所研究的浓度范围内，溶液中必定存在两种异构体1:1配合物。在298K时，总的缔合常数为113M。当浓度小于1.0×10⁻³M时，该配合物完全解离。
