Uccello-Barretta G, Chiavacci C, Bertucci C, Salvadori P
Centro di Studio del CNR per le Macromolecole Stereordinate ed Otticamente Attive, Dipartimento di Chimica e Chimica Industriale, Pisa, Italy.
Carbohydr Res. 1993 Apr 23;243(1):1-10. doi: 10.1016/0008-6215(93)84077-j.
The inclusion complex of the calcium salt of (S)-2-(3-phenoxyphenyl)propionic acid with cyclomaltoheptaose (beta-cyclodextrin) was investigated by 1H NMR spectroscopy. The stoichiometry of the complex was determined by the continuous variation method and the association constant by the Benesi-Hildebrand procedure. Measurements of proton selective relaxation rates allowed the dynamics of the complex to be investigated and the determination of intermolecular 1H(1H)-NOE enhancements revealed the stereochemistry in solution.
采用核磁共振氢谱（1H NMR）对（S）-2-（3-苯氧基苯基）丙酸钙盐与环麦芽七糖（β-环糊精）的包合物进行了研究。通过连续变化法确定了该包合物的化学计量比，并采用贝内西-希尔德布兰德（Benesi-Hildebrand）方法测定了缔合常数。通过测量质子选择性弛豫速率来研究该包合物的动力学，分子间1H（1H）-NOE增强效应的测定揭示了溶液中的立体化学。
