Erlenmeyer-Kimling L, Cornblatt B A
Department of Medical Genetics, New York State Psychiatric Institute, New York 10032.
J Psychiatr Res. 1992 Oct;26(4):405-26. doi: 10.1016/0022-3956(92)90043-n.
We summarize here our findings with respect to attentional impairment among offspring of schizophrenic, affectively ill, and normal parents followed from childhood to adulthood during the two decades of the New York High-Risk Project (NYHRP). We review our data first, on childhood attentional performance in each of our two independent samples of such subjects and, second, on the relationship of early dysfunctions observed in this domain to psychopathological outcomes in adolescence and adulthood. Our cumulative results contribute strong support to the contention that global attentional dysfunctions may be viewed as a biobehavioral marker for the genetic liability to schizophrenic disorders.
在此，我们总结了纽约高危项目（NYHRP）在二十年期间对精神分裂症患者、情感障碍患者及正常父母的子女从童年到成年进行跟踪研究后，有关注意力损害方面的研究结果。我们首先回顾在这两类独立样本对象中关于童年注意力表现的数据，其次回顾在该领域观察到的早期功能障碍与青少年及成年期精神病理结果之间的关系。我们的累积研究结果有力支持了这样一种观点，即整体注意力功能障碍可被视为精神分裂症遗传易感性的一种生物行为标志物。
