Baron M, Gruen R S
Columbia University College of Physicians and Surgeons, New York.
Br J Psychiatry. 1991 Aug;159:267-70. doi: 10.1192/bjp.159.2.267.
The relationship between schizophrenic 'spectrum' disorders and affective illness was studied in the nuclear families of 90 chronic schizophrenic probands. An increased risk of schizophrenia and related disorders was demonstrated among the first-degree relatives of probands with a family history of major affective disorders. Conversely, relatives of probands with a family history of schizophrenic 'spectrum' disorders were at a greater risk of affective illness (major depression) than relatives of probands with no family history. These results lend support to the notion that a subset of affective disorders is associated with the liability to schizophrenia.
在90名慢性精神分裂症先证者的核心家庭中，研究了精神分裂症“谱系”障碍与情感性疾病之间的关系。在有重性情感障碍家族史的先证者的一级亲属中，精神分裂症及相关障碍的风险增加。相反，有精神分裂症“谱系”障碍家族史的先证者的亲属比无家族史的先证者的亲属患情感性疾病（重度抑郁症）的风险更大。这些结果支持了这样一种观点，即一部分情感障碍与精神分裂症易感性有关。
