Otu A A
Department of Surgery, College of Medical Sciences, University of Calabar, Nigeria.
J R Coll Surg Edinb. 1992 Dec;37(6):405-7.
In an attempt to provide an alternative non-invasive treatment to surgical excision of ganglion cysts of the hand, and as part of the departmental audit resulting from the prevailing economic depression, 340 consecutive patients with 349 ganglia were treated in a prospective investigation by intralesional injection of hyaluronidase (up to 150 units in 1 ml) followed by fine needle aspiration (FNA) of the cyst to dryness. Pressure was applied over a piece of gauze and maintained with a crepe bandage for 24 h. Of the 340 patients treated in this way, the vast majority (323 or 95.0%) were considered to be cured on clinical examination at 6-month follow-up; only 17 patients (5.0%) exhibited recurrence during this period and these were successfully treated by re-aspiration. To the knowledge of this author, this is the first report of the use of the enzyme hyaluronidase as an adjunct to FNA in the treatment of ganglion cysts of the hand. The results clearly show that this method of treatment is a safe, fast, well accepted and cost-effective alternative to surgical excision, which is relatively expensive and is known to be associated with certain complications, including hypertrophic scars and cheloids.
为了提供一种替代手术切除手部腱鞘囊肿的非侵入性治疗方法，并且作为当前经济衰退导致的科室审计的一部分，对340例连续患者的349个腱鞘囊肿进行了一项前瞻性研究，采用病灶内注射透明质酸酶（1ml中最多150单位），随后对囊肿进行细针穿刺抽吸（FNA）直至干燥。在一块纱布上施加压力，并用弹力绷带维持24小时。以这种方式治疗的340例患者中，绝大多数（323例或95.0%）在6个月随访的临床检查中被认为已治愈；在此期间只有17例患者（5.0%）出现复发，这些患者通过再次抽吸成功治愈。据作者所知，这是首次报道使用酶透明质酸酶辅助FNA治疗手部腱鞘囊肿。结果清楚地表明，这种治疗方法是一种安全、快速、易于接受且具有成本效益的替代手术切除的方法，手术切除相对昂贵且已知会伴有某些并发症，包括肥厚性瘢痕和瘢痕疙瘩。
