氮芥作为类风湿关节炎的诱导治疗：临床和免疫学效应
Nitrogen mustard as induction therapy for rheumatoid arthritis: clinical and immunologic effects.
作者信息
Danao T, Ropos T, Wilke W, Segal A, Calabrese L, Valenzuela R, Gragg L, Clough J
机构信息
Department of Rheumatic and Immunologic Disease, Cleveland Clinic Foundation, Ohio 44195.
出版信息
J Rheumatol. 1992 Nov;19(11):1683-6.
We treated 5 patients diagnosed with rheumatoid arthritis (RA) with nitrogen mustard (HN2) and monitored clinical and immunologic variables. HN2, 0.3 mg/kg ideal body weight was given over 7 days. Disease activity and immune function were monitored during and after treatment. Duration of morning stiffness (p = 0.0044), joint count (p = 0.0140), and assessment of pain (p = 0.0264) and function (p = 0.0057) improved by Day 6. T lymphocytes (p = 0.0060), especially T memory cells (CD4CD29; p = 0.0017) fell dramatically. HN2 is effective for rapidly gaining control of active RA. This effect is T cell specific.
我们用氮芥（HN2）治疗了5例诊断为类风湿性关节炎（RA）的患者，并监测了临床和免疫学变量。以0.3 mg/kg理想体重的氮芥持续给药7天。在治疗期间及治疗后监测疾病活动和免疫功能。到第6天时，晨僵持续时间（p = 0.0044）、关节计数（p = 0.0140）以及疼痛评估（p = 0.0264）和功能评估（p = 0.0057）均有所改善。T淋巴细胞（p = 0.0060），尤其是T记忆细胞（CD4CD29；p = 0.0017）显著减少。氮芥对于迅速控制活动期类风湿性关节炎有效。这种作用具有T细胞特异性。
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