Moreland L W, Reddy M S, Koopman W J, Webber R L, Alarcón G S, Jeffcoat M K
Department of Medicine, School of Medicine, University of Alabama, Birmingham 35294-0012.
J Rheumatol. 1992 Nov;19(11):1697-703.
A digital subtraction radiography (DSR) method was developed to assess changes of bony erosions in the hands of patients with rheumatoid arthritis (RA). The method initially was validated in vitro using simulated lesions in cadaver hands. The sensitivity, specificity and accuracy in detecting simulated lesions were 84.6, 100, and 92.3%, respectively. This technique was then pilot tested clinically using 17 patients with RA and 5 controls with no arthritis. All subjects received the nonsteroidal antiinflammatory drug, flurbiprofen, during the 6-month study period. No progressive changes in bone were observed in the control group; however, 18% of the target joints studied in the group with RA showed significant erosive changes (positive or negative) which correlated with the clinical assessment. The results indicate that DSR may be useful in detecting small changes in erosions on hand/wrist radiographs of patients with RA.
一种数字减影放射成像（DSR）方法被开发出来，用于评估类风湿性关节炎（RA）患者手部骨质侵蚀的变化。该方法最初在体外使用尸体手部的模拟病变进行验证。检测模拟病变的敏感性、特异性和准确性分别为84.6%、100%和92.3%。然后，该技术在临床上对17例RA患者和5例无关节炎的对照者进行了初步测试。在6个月的研究期间，所有受试者均服用非甾体抗炎药氟比洛芬。对照组未观察到骨骼的进展性变化；然而，RA组中18%的研究目标关节出现了与临床评估相关的显著侵蚀性变化（阳性或阴性）。结果表明，DSR可能有助于检测RA患者手部/腕部X光片上侵蚀的微小变化。
