Bolander M E, Gardiner J, Coyle J, Joyce M, Himmel H H, Thornton B C, Ruttimann U E
Orthopaedic Research Unit, National Institute of Arthritis, Musculoskeletal, and Skin Diseases, NIH, Bethesda, MD 20892.
Invest Radiol. 1990 Jun;25(6):708-13. doi: 10.1097/00004424-199006000-00016.
The ability of digital subtraction radiography, a new technique to detect and quantify small bone lesions, is demonstrated. Discrete lesions in the metacarpals of cadaver hands simulated erosive bone loss. Radiographs made before and after removal of bone were digitized and subtracted. Density changes on subtraction images were determined, and bone loss was estimated by an automatic procedure that compared changes in radiographic density with a calibration wedge included in the radiographs. Comparison of estimated bone loss with the weight of bone removed showed reproducible detection and measurement of bone lesions as small as 4.6 mg, a size undetectable using current radiographic methods. Subtraction radiographs of bone chips overlaid on the hand of a volunteer indicated detection limits were similar in vivo. This technique enhanced the radiographic visibility of erosive lesions and thus has the potential to improve the detection of subtle bone changes in clinical settings.
数字减影放射成像技术是一种用于检测和量化小骨病变的新技术，其能力得到了证明。在尸体手部掌骨中的离散病变模拟了侵蚀性骨质流失。去除骨质前后拍摄的X光片被数字化并进行相减。确定了减影图像上的密度变化，并通过一种自动程序估计骨质流失，该程序将放射密度的变化与X光片中包含的校准楔进行比较。将估计的骨质流失与去除的骨重量进行比较，结果表明，该技术可重复性地检测和测量小至4.6毫克的骨病变，这是目前放射成像方法无法检测到的尺寸。覆盖在志愿者手部的骨碎片的减影X光片表明，体内的检测限与此相似。该技术提高了侵蚀性病变的放射成像可见性，因此有可能改善临床环境中细微骨变化的检测。
