Alarcón-Segovia D
Department of Immunology and Rheumatology, Instituto Nacional de la Nutrición Salvador Zubirán, Mexico, DF.
J Rheumatol. 1992 Nov;19(11):1778-81.
We studied a large cohort of patients with systemic lupus erythematosus (SLE) to determine which manifestations associate with the antiphospholipids (aPL) and to ascertain when 2 or more such manifestations coexist, the association with aPL is stronger and the titers tend to be higher. We have confirmed that when aPL occur within SLE, they may account for some disease manifestations. We also described a similar syndrome occurring in the absence of a primary condition which we termed primary antiphospholipid syndrome (APS). Thus, we were able to construct preliminary criteria for the classification of APS as it occurs in SLE. With appropriate additions and exclusions to rule out SLE, these criteria could be applied to the classification of primary APS.
我们研究了一大群系统性红斑狼疮（SLE）患者，以确定哪些表现与抗磷脂（aPL）相关，并确定当两种或更多种此类表现同时存在时，与aPL的关联是否更强且滴度往往更高。我们已经证实，当aPL出现在SLE中时，它们可能导致一些疾病表现。我们还描述了一种在无原发性疾病情况下出现的类似综合征，我们将其称为原发性抗磷脂综合征（APS）。因此，我们能够构建SLE中发生的APS分类的初步标准。通过适当增加和排除以排除SLE，这些标准可应用于原发性APS的分类。
