Yeh C K, Fox P C, Goto Y, Austin H A, Brahim J S, Fox C H
Clinical Investigations and Patient Care Branch, NIDR, National Institutes, of Health, Bethesda, MD 20892.
J Rheumatol. 1992 Nov;19(11):1810-2.
A young woman with systemic lupus erythematosus (SLE) was infected with human immunodeficiency virus 1 (HIV-1) and about 6 years later developed persistent bilateral parotid gland enlargement. It was unclear whether this represented salivary gland involvement as a component of her SLE (secondary Sjögren's syndrome) or the initial clinical manifestation of her HIV-1 infection. HIV proviral DNA was found in individual salivary glandular secretions and in whole saliva. Additionally, cells positive for HIV RNA were isolated from whole saliva. A parotid gland biopsy revealed infiltrating lymphocytes containing large amounts of HIV RNA.
