Schiødt M, Atkinson J C, Greenspan D, Fox P C, Dodd C L, Daniels T E, Greenspan J S
Department of Stomatology, University of California, San Francisco.
J Rheumatol. 1992 Jan;19(1):26-9.
Human immunodeficiency virus (HIV) associated salivary gland disease is defined as the presence of enlargement of one or more major salivary glands and/or diminished salivary function in an HIV infected individual. It has a number of similarities to, as well as differences from, Sjögren's syndrome (SS). We studied the sialochemistry of stimulated parotid saliva of 11 patients with HIV associated salivary gland disease and bilateral parotid gland enlargement, and compared these findings with those of 15 HIV negative controls, 13 HIV positive individuals with no salivary gland involvement and 18 individuals with SS. The patients with HIV associated salivary gland disease had a significant decrease in the level of salivary protein, with increases in salivary IgA, lysozyme and albumin compared to the HIV negative controls. There were no changes in concentration of electrolytes. The sialochemistry among the patients with HIV associated salivary gland disease was unrelated to the degree of immune suppression and did not change over a 6 month period. The observed changes were similar to those of SS but less pronounced. The similar clinical, histologic and sialochemical features of HIV associated salivary gland disease and SS suggest that these conditions share common pathogenetic mechanisms, which may be modified in the former by the HIV infection.
人类免疫缺陷病毒（HIV）相关涎腺疾病的定义为，HIV感染个体出现一个或多个主要涎腺肿大和/或涎腺功能减退。它与干燥综合征（SS）有一些相似之处，也有不同之处。我们研究了11例患有HIV相关涎腺疾病且双侧腮腺肿大患者的腮腺刺激唾液的涎腺化学组成，并将这些结果与15例HIV阴性对照、13例无涎腺受累的HIV阳性个体以及18例SS患者的结果进行比较。与HIV阴性对照相比，HIV相关涎腺疾病患者的唾液蛋白水平显著降低，唾液IgA、溶菌酶和白蛋白水平升高。电解质浓度无变化。HIV相关涎腺疾病患者的涎腺化学组成与免疫抑制程度无关，且在6个月内无变化。观察到的变化与SS相似，但不那么明显。HIV相关涎腺疾病和SS相似的临床、组织学和涎腺化学特征表明，这些疾病具有共同的发病机制，在前者中可能因HIV感染而发生改变。
