Makino H
Third Department of Internal Medicine, Okayama University Medical School.
Nihon Rinsho. 1992 Dec;50(12):3038-45.
Many renal diseases progress to end-stage renal failure with glomerulosclerosis, irrespective of the cause of the disease. Glomerulosclerosis is characterized by an accumulation of extracellular matrices (ECM) due to increased synthesis of the ECM and/or decreased degradation of the ECM. Sclerotic lesions represent an accumulation of normal constituents of the ECM, including type IV collagen, laminin, proteoglycans, as well as, abnormal constituents such as type I and III collagens. The cDNAs for various ECM constituents have been obtained and it has become possible to study the status of their synthesis, in the transcriptional level, in various glomerular diseases. Studies suggest that hemodynamic factors and growth factors, such as, TGF-beta and PDGF are responsible for the development of glomerulosclerosis. Inappropriate expression of intrinsic mesangial cell metalloproteinases and tissue inhibitors of metalloproteinases also lead to glomerulosclerosis.
许多肾脏疾病都会发展为伴有肾小球硬化的终末期肾衰竭，无论其病因如何。肾小球硬化的特征是细胞外基质（ECM）的积累，这是由于ECM合成增加和/或ECM降解减少所致。硬化性病变代表了ECM正常成分的积累，包括IV型胶原、层粘连蛋白、蛋白聚糖，以及I型和III型胶原等异常成分。已经获得了各种ECM成分的cDNA，并且在转录水平上研究它们在各种肾小球疾病中的合成状态成为可能。研究表明，血流动力学因素和生长因子，如转化生长因子-β（TGF-β）和血小板衍生生长因子（PDGF），是肾小球硬化发展的原因。固有系膜细胞金属蛋白酶和金属蛋白酶组织抑制剂的不适当表达也会导致肾小球硬化。
