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通过将转化生长因子-β或血小板衍生生长因子基因体内转染至大鼠肾脏所诱导的肾小球硬化。

Glomerulosclerosis induced by in vivo transfection of transforming growth factor-beta or platelet-derived growth factor gene into the rat kidney.

作者信息

Isaka Y, Fujiwara Y, Ueda N, Kaneda Y, Kamada T, Imai E

机构信息

First Department of Medicine, Osaka University Medical School, Japan.

出版信息

J Clin Invest. 1993 Dec;92(6):2597-601. doi: 10.1172/JCI116874.

DOI:10.1172/JCI116874
PMID:8254017
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC288455/
Abstract

Glomerulosclerosis, a final common lesion of various glomerular diseases, is characterized by mesangial cell proliferation and extracellular matrix (ECM) expansion. TGF-beta and PDGF are known to play a critical role in the regulation of ECM metabolism and mesenchymal cell proliferation, respectively. However, there is little evidence to demonstrate the direct role of each of these growth factors in the pathogenesis of glomerulosclerosis. Using an in vivo transfection technique, we could realize the selective overexpression of single growth factor in the kidney. The introduction of either TGF-beta or PDGF-B gene alone into the kidney induced glomerulosclerosis, although the patterns of action of these growth factors were different; TGF-beta affected ECM accumulation rather than cell proliferation and PDGF affected the latter rather than the former.

摘要

肾小球硬化是各种肾小球疾病的最终共同病变，其特征为系膜细胞增殖和细胞外基质（ECM）扩张。已知转化生长因子-β（TGF-β）和血小板衍生生长因子（PDGF）分别在ECM代谢调节和间充质细胞增殖中起关键作用。然而，几乎没有证据表明这些生长因子中的每一种在肾小球硬化发病机制中的直接作用。使用体内转染技术，我们能够在肾脏中实现单一生长因子的选择性过表达。单独将TGF-β或PDGF-B基因导入肾脏均可诱导肾小球硬化，尽管这些生长因子的作用模式不同；TGF-β影响ECM积聚而非细胞增殖，而PDGF影响后者而非前者。

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