铜绿假单胞菌临床菌株中抗生素耐药性的模式及传播性。

The patterns and transmissibility of antibiotic resistance among clinical strains of Pseudomonas aeruginosa.

作者信息

Palillo E S, Salleh M A

机构信息

Department of Genetics, Faculty of Life Sciences, National University of Malaysia, Selangor.

出版信息

Microbiol Immunol. 1992;36(11):1195-200. doi: 10.1111/j.1348-0421.1992.tb02122.x.

DOI:10.1111/j.1348-0421.1992.tb02122.x

PMID:1491621

Abstract

Four hundred and ninety-eight predominantly pyocin-type 10 clinical strains of Pseudomonas aeruginosa were analyzed for resistance to carbenicillin, cefoperazone, cefotaxime, ceftazidime, gentamicin, amikacin and netilmicin. Based on NCCLS-recommended MIC breakpoints, 245 strains were found to be resistant, of which 41.6% were resistant to carbenicillin, 38% to gentamicin, 37.8% to netilmicin, 26.3% to cefoperazone, 17.9% to cefotaxime, 0.6% to amikacin and none to ceftazidime. Quadruple resistance to carbenicillin, cefoperazone, gentamicin and netilmicin was the most frequent pattern observed. Resistance to older antibiotics (kanamycin, streptomycin and tetracycline) and to mercuric chloride were also common. Conjugation experiments suggested that self-transmissible and non-transmissible plasmids occurred in at least 66 strains.

摘要

对498株主要为10型绿脓菌素的铜绿假单胞菌临床菌株进行了对羧苄青霉素、头孢哌酮、头孢噻肟、头孢他啶、庆大霉素、阿米卡星和奈替米星耐药性的分析。根据美国国家临床实验室标准委员会（NCCLS）推荐的最低抑菌浓度（MIC）断点，发现245株菌株耐药，其中41.6%对羧苄青霉素耐药，38%对庆大霉素耐药，37.8%对奈替米星耐药，26.3%对头孢哌酮耐药，17.9%对头孢噻肟耐药，0.6%对阿米卡星耐药，对头孢他啶无耐药。对羧苄青霉素、头孢哌酮、庆大霉素和奈替米星的四重耐药是观察到的最常见模式。对较老的抗生素（卡那霉素、链霉素和四环素）以及对氯化汞的耐药也很常见。接合实验表明，至少66株菌株中存在自我传递和非传递质粒。