环丙沙星及其他β-内酰胺类抗生素对庆大霉素和羧苄西林耐药的铜绿假单胞菌分离株的体外活性
In-vitro activity of ciprofloxacin and other beta-lactam antibiotics against gentamicin- and carbenicillin-resistant isolates of Pseudomonas aeruginosa.
作者信息
Sofianou D C, Douboyas J P
机构信息
Department of Medical Microbiology, Aristotelian University of Thessaloniki, Greece.
出版信息
J Chemother. 1991 Feb;3(1):3-5. doi: 10.1080/1120009x.1991.11739054.
The susceptibilities of gentamicin- and carbenicillin-resistant clinical isolates of Pseudomonas aeruginosa to newer beta-lactams, netilmicin and ciprofloxacin were studied by a broth microdilution technique. Imipenem, aztreonam and ceftazidime were active against most of the P. aeruginosa strains with minimum inhibitory concentration (MIC) for 90% of the isolates at clinically achievable levels. Piperacillin, azlocillin, cefotaxime, ceftriaxone, cefsulodin, cefoperazone and netilmicin showed poor activity against these organisms, ciprofloxacin exhibited poor activity, inhibiting only 30% of these strains.
采用肉汤微量稀释技术研究了庆大霉素和羧苄青霉素耐药的铜绿假单胞菌临床分离株对新型β-内酰胺类抗生素、奈替米星和环丙沙星的敏感性。亚胺培南、氨曲南和头孢他啶对大多数铜绿假单胞菌菌株有活性，90%分离株的最低抑菌浓度（MIC）处于临床可达到的水平。哌拉西林、阿洛西林、头孢噻肟、头孢曲松、头孢磺啶、头孢哌酮和奈替米星对这些菌株活性较差，环丙沙星活性也较差，仅能抑制30%的这些菌株。
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