Sirviö J, Ekonsalo T, Riekkinen P, Lahtinen H, Riekkinen P
Department of Neurology, University of Kuopio, Finland.
Neurosci Lett. 1992 Nov 9;146(2):215-8. doi: 10.1016/0304-3940(92)90081-h.
The results of the present study indicate that D-cycloserine, a partial agonist at the glycine binding site, which is a positive modulation site of the N-methyl-D-aspartate receptor, could improve dose dependently the acquisition of a water maze task in rats treated with scopolamine, a muscarinic antagonist. The low to moderate doses of D-cycloserine which improved learning did not affect swimming speed in scopolamine-treated rats. The higher dose did not improve learning, but it increased swimming speed in scopolamine-treated rats. These results show a dissociation between impaired acquisition and abnormal behavioral activity in scopolamine-treated rats in the water maze task. Furthermore, the present results suggest that D-cycloserine can act as a cognitive enhancer at the appropriate doses.
本研究结果表明，D-环丝氨酸作为甘氨酸结合位点的部分激动剂（该位点是N-甲基-D-天冬氨酸受体的正向调节位点），可剂量依赖性地改善用毒蕈碱拮抗剂东莨菪碱处理的大鼠在水迷宫任务中的习得能力。改善学习能力的低至中等剂量的D-环丝氨酸对用东莨菪碱处理的大鼠的游泳速度没有影响。较高剂量并未改善学习能力，但却提高了用东莨菪碱处理的大鼠的游泳速度。这些结果表明，在水迷宫任务中，用东莨菪碱处理的大鼠在习得能力受损和异常行为活动之间存在分离。此外，目前的结果表明，D-环丝氨酸在适当剂量下可作为一种认知增强剂。
