Baxter M G, Lanthorn T H, Frick K M, Golski S, Wan R Q, Olton D S
Department of Psychology, Johns Hopkins University, Baltimore, MD 21218.
Neurobiol Aging. 1994 Mar-Apr;15(2):207-13. doi: 10.1016/0197-4580(94)90114-7.
D-cycloserine, a partial agonist of the NMDA receptor-associated glycine site, can enhance cognition. The present experiment examines the behavioral effects of D-cycloserine on cognitive deficits in male Fischer-344 rats, 24 months old. Rats 24 months old (n = 42) received either vehicle or one of 3 doses of D-cycloserine prior to testing. Young rats, 4 months old (n = 13), received vehicle prior to testing. Place discrimination and repeated acquisition were tested in the water maze and a variety of sensorimotor tasks were given. Aging impaired performance in all tasks. D-cycloserine improved performance in place discrimination and repeated acquisition. No doses affected sensorimotor function. These results support the hypothesis that D-cycloserine has cognition enhancing properties and that it may be useful in treating disorders involving cognitive impairment.
D-环丝氨酸是N-甲基-D-天冬氨酸（NMDA）受体相关甘氨酸位点的部分激动剂，能够增强认知能力。本实验研究了D-环丝氨酸对24月龄雄性Fischer-344大鼠认知缺陷的行为学影响。24月龄大鼠（n = 42）在测试前接受了溶剂对照或3种剂量的D-环丝氨酸之一。4月龄幼鼠（n = 13）在测试前接受了溶剂对照。在水迷宫中测试位置辨别和重复习得，并进行了各种感觉运动任务。衰老损害了所有任务的表现。D-环丝氨酸改善了位置辨别和重复习得的表现。没有剂量影响感觉运动功能。这些结果支持了以下假设：D-环丝氨酸具有认知增强特性，可能对治疗涉及认知障碍的疾病有用。
