Pawelzik H, Dodt H U, Zieglgänsberger W
Max-Planck-Institute of Psychiatry, Clinical Institute, München, FRG.
Neurosci Lett. 1992 Dec 7;147(2):167-70. doi: 10.1016/0304-3940(92)90586-v.
The action of vasoactive intestinal polypeptide (VIP) was studied using intracellular recording techniques in neocortical neurons of the rat in vitro. When added to the perfusion medium, VIP enhanced direct excitability and increased the amplitude of the excitatory postsynaptic potential (EPSP). Effects of VIP were long-lasting and in most cases not fully reversible within the observation period. The present results suggest a role for VIP in long-lasting peptidergic modulation of excitatory synaptic components as well as direct excitability of neocortical pyramidal neurons of the adult rat.
采用细胞内记录技术，在体外对大鼠新皮质神经元进行研究，以探讨血管活性肠多肽（VIP）的作用。当将VIP添加到灌流液中时，它增强了直接兴奋性，并增加了兴奋性突触后电位（EPSP）的幅度。VIP的作用持久，在大多数情况下，在观察期内不能完全逆转。目前的结果表明，VIP在成年大鼠新皮质锥体神经元兴奋性突触成分的持久肽能调节以及直接兴奋性方面发挥作用。
