Honma S, Kanematsu N, Katsuno Y, Honma K
Department of Physiology, Hokkaido University School of Medicine, Sapporo, Japan.
Neurosci Lett. 1992 Dec 7;147(2):201-4. doi: 10.1016/0304-3940(92)90595-x.
Effects of light on the pineal and plasma melatonin were examined in Wistar and Long-Evans rats at two different times in the dark phase (light off from 18.00 h to 06.00 h) using lights of two different monochromatic wavelengths but with the same irradiance. The green light pulse (520 nm) given at 24.00 h suppressed the pineal and plasma melatonin to the day-time level for at least 2 h, while the red light (660 nm) pulse given at the same time of the day suppressed pineal melatonin only transiently and did not suppress the plasma melatonin at all. Both green and red lights given at 4.00 h suppressed the pineal and plasma melatonin to a similar extent. The results demonstrated that the suppression of melatonin by light depends on the wavelength of light and the circadian phase.
在黑暗期的两个不同时间点（熄灯时间为18:00至06:00），使用两种不同单色波长但辐照度相同的光，研究了光照对Wistar和Long-Evans大鼠松果体及血浆褪黑素的影响。24:00给予的绿光脉冲（520纳米）可将松果体及血浆褪黑素抑制至白天水平至少2小时，而在同一天的同一时间给予的红光（660纳米）脉冲仅短暂抑制松果体褪黑素，对血浆褪黑素则完全没有抑制作用。4:00给予的绿光和红光对松果体及血浆褪黑素的抑制程度相似。结果表明，光照对褪黑素的抑制作用取决于光的波长和昼夜节律相位。
