Belcaro G, Laurora G, Cesarone M R, De Sanctis M T, Renton S, Veller M, Fisher C, Nicolaides A N
Microcirculation Laboratory, G. D'Annunzio University, Chieti, Italy.
Panminerva Med. 1992 Jul-Sep;34(3):107-14.
The evaluation of early arterial lesions and the follow-up of the progression of arteriosclerotic wall changes is possible with high resolution ultrasound. While dynamic (duplex scanning) data are suitable for the follow-up of advanced stenosis and plaques, the morphological evaluation performed using the technique of non-invasive ultrasonic biopsy may be used to follow-up early lesions and their progression. The data obtained by ultrasonic biopsy are related to the incidence of occult coronary ischemia and to the occurrence of cardiovascular events in 4 years. The rate of progression (ROP) to the next, more advanced UB class can be also evaluated by ultrasonic biopsy. It has been shown that in diabetic and hyperlipidemic subjects the ROP is higher. Also in interventional studies using lipid lowering agents (with a four-year follow-up) a reduction in ROP in treated asymptomatic hyperlipidemic subjects in comparison with controls has been documented. The combination of dynamic data and morphological data gives us a complete evaluation of the vascular system both for the assessment of single individuals and for large population studies.
利用高分辨率超声能够评估早期动脉病变，并对动脉粥样硬化血管壁变化的进展情况进行随访。虽然动态（双功扫描）数据适用于对晚期狭窄和斑块进行随访，但采用非侵入性超声活检技术进行的形态学评估可用于随访早期病变及其进展。通过超声活检获得的数据与隐匿性冠状动脉缺血的发生率以及4年内心血管事件的发生情况相关。超声活检还可评估进展至下一个更高级别超声活检类别的进展率（ROP）。研究表明，糖尿病和高脂血症患者的ROP更高。在使用降脂药物的干预性研究（随访四年）中，也有记录显示，与对照组相比，接受治疗的无症状高脂血症患者的ROP有所降低。动态数据和形态学数据相结合，使我们能够对血管系统进行全面评估，无论是用于个体评估还是大规模人群研究。
