Cesarone M R, Laurora G, De Sanctis M T, Belcaro G
Laboratorio di Microcircolazione, Università degli Studi di Chieti.
Minerva Cardioangiol. 1991 Nov;39(11):421-6.
Two thousand normal subjects and 600 vascular patients, divided into 9 age groups were studied with the techniques of the "ultrasonic biopsy" based on high resolution scans of the arterial walls. Subjects in Class I had normal walls while patients in Class V were asymptomatic with complex plaques and those in Class VI were symptomatic. The variation in UB score (the score relative to the classes) with age was found to be proportional to age. Also the UB score was significantly higher in vascular patients. The incidence of occult coronary ischemia was increasingly high in the 6 classes and the incidence of cardiovascular events in 4 years was proportionally higher in Class V and VI. No events were observed in patients belonging to Class I and II. The progression of arterial changes in 4 years in the patients of each class was observed.
对2000名正常受试者和600名血管疾病患者进行了研究，这些患者被分为9个年龄组，采用基于动脉壁高分辨率扫描的“超声活检”技术。I类受试者动脉壁正常，V类患者无症状但有复杂斑块，VI类患者有症状。发现UB评分（相对于类别而言的评分）随年龄的变化与年龄成正比。此外，血管疾病患者的UB评分显著更高。隐匿性冠状动脉缺血的发生率在这6个类别中越来越高，V类和VI类患者4年内心血管事件的发生率也成比例地更高。I类和II类患者未观察到事件。观察了每个类别的患者4年中动脉变化的进展情况。
