Burrington J D
J Thorac Cardiovasc Surg. 1978 Jun;75(6):819-26.
The following conditions were surgically created in fetal lambs at the gestational ages of 80 to 90 days: (1) preductal coarctation, (2) postductal coarctation, (3) pulmonic stenosis, and (4) constriction of the ductus arteriosus. Studies performed at the time of delivery showed the following: Preductal coarctation and postductal coarctation often are associated with a dilated ductus arteriosus that remains patent. Pulmonic stenosis often results in prestenotic and poststenotic dilatation that may include the ductus arteriosus. The fetal ventricles become hypertrophied in response to the increased pressure work imposed by the distal stenoses.
在妊娠80至90天的胎羊中通过手术制造了以下情况：（1）导管前缩窄，（2）导管后缩窄，（3）肺动脉狭窄，以及（4）动脉导管缩窄。分娩时进行的研究显示如下：导管前缩窄和导管后缩窄常与持续开放的扩张动脉导管相关。肺动脉狭窄常导致狭窄前和狭窄后扩张，这可能包括动脉导管。胎儿心室因远端狭窄施加的压力增加而肥厚。
