Elzenga N J, Gittenberger-de Groot A C
Br Heart J. 1983 Apr;49(4):317-23. doi: 10.1136/hrt.49.4.317.
Localised coarctation of the aorta was studied histologically in 45 cases. The age range of the patients, from 2 weeks to 40 years, enabled us to make a comparison between early and late findings. The basic histological architecture of all coarctations was identical. The ridge consisted mainly of thickening plus some infolding of the aortic wall. Ductal tissue formed the inner part of the ridge for more than half of its total circumference. In older cases masses of secondary intimal proliferation were present, which narrowed the residual lumen of the coarctation. The coarctation was located preductally in most young patients and postductally in the majority of older patients. It is concluded that ductal tissue is invariably present in the ridge and that all coarctations develop in a preductal position. Secondary changes include a gradual shift of the ridge from a preductal to a postductal position, and progressive narrowing of the residual lumen by intimal proliferation.
对45例主动脉局限性缩窄进行了组织学研究。患者年龄范围从2周龄至40岁，这使我们能够对早期和晚期的研究结果进行比较。所有缩窄的基本组织结构相同。缩窄嵴主要由主动脉壁增厚及部分内褶构成。在超过一半的缩窄嵴总周长中，导管组织构成了其内部部分。在年龄较大的病例中，存在继发性内膜增生团块，这使缩窄的残余管腔变窄。大多数年轻患者的缩窄位于动脉导管前，而大多数老年患者的缩窄位于动脉导管后。得出的结论是，缩窄嵴中始终存在导管组织，且所有缩窄均在动脉导管前位置形成。继发性改变包括缩窄嵴从动脉导管前位置逐渐向动脉导管后位置移位，以及内膜增生导致残余管腔逐渐变窄。
