Baddour L M, Busby L, Shapiro E, Cox K B, Glassco S, Johnson J K
Department of Medicine, University of Tennessee Medical Center, Knoxville.
Sex Transm Dis. 1992 Nov-Dec;19(6):341-5.
This study compared ampicillin/sulbactam plus probenecid with ceftriaxone for treatment of uncomplicated gonorrhea. Of the 297 men and women who were enrolled and randomized to receive either ampicillin/sulbactam (1.0 g/0.5 g) with probenecid (1 g) or ceftriaxone (0.25 g), 274 patients were evaluable. Both ampicillin/sulbactam and ceftriaxone were administered by intramuscular injections. Patients were gonococcal contacts, had positive culture results for Neisseria gonorrhoeae, or had clinical evidence of gonorrhea. Specimens for gonococcal cultures were collected from the cervix (female patients), urethra, rectum, and pharynx at pretreatment and test-of-cure visits. The presence of N. gonorrhoeae and a test-of-cure visit were required for drug efficacy analysis. Of the 274 evaluable patients, 195 (71.2%) had positive culture results for N. gonorrhoeae. Cure was achieved in 93 (94.9%) of 98 patients receiving ampicillin/sulbactam with probenecid and in 96 (99.0%) of 97 patients receiving ceftriaxone. Penicillinase-producing N. gonorrhoeae strains were found in 21 (10.8%) patients; these were eradicated by either ampicillin/sulbactam with probenecid (N = 9) or ceftriaxone (N = 12). Overall, the two drug regimens were very well tolerated and no serious adverse effects were noted. Ampicillin/sulbactam with probenecid may be useful as single-dose therapy in patients with uncomplicated genitorectal gonorrhea.
本研究比较了氨苄西林/舒巴坦加丙磺舒与头孢曲松治疗单纯性淋病的疗效。297名男女受试者被纳入研究并随机分为两组，分别接受氨苄西林/舒巴坦（1.0g/0.5g）加丙磺舒（1g）或头孢曲松（0.25g）治疗，其中274例患者可进行评估。氨苄西林/舒巴坦和头孢曲松均通过肌肉注射给药。患者均为淋病接触者，淋病奈瑟菌培养结果呈阳性，或有淋病的临床证据。在治疗前和治愈检查时，从宫颈（女性患者）、尿道、直肠和咽部采集淋病奈瑟菌培养标本。药物疗效分析需要有淋病奈瑟菌存在以及进行治愈检查。在274例可评估患者中，195例（71.2%）淋病奈瑟菌培养结果呈阳性。接受氨苄西林/舒巴坦加丙磺舒治疗的98例患者中有93例（94.9%）治愈，接受头孢曲松治疗的97例患者中有96例（99.0%）治愈。在21例（10.8%）患者中发现了产青霉素酶的淋病奈瑟菌菌株；这些菌株被氨苄西林/舒巴坦加丙磺舒（9例）或头孢曲松（12例）根除。总体而言，两种药物治疗方案的耐受性都非常好，未观察到严重不良反应。氨苄西林/舒巴坦加丙磺舒可作为单纯性泌尿生殖道淋病患者的单剂量治疗药物。
