Portilla I, Lutz B, Montalvo M, Mogabgab W J
Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70112.
Sex Transm Dis. 1992 Mar-Apr;19(2):94-8.
A randomized trial was conducted to compare cefixime (400 mg or 800 mg single oral dose) with ceftriaxone (250 mg single intramuscular dose) in terms of efficacy and safety for the treatment of uncomplicated Neisseria gonorrhoeae urethritis or cervicitis. Of 75 men and 150 women screened, 187 had positive culture results for N. gonorrhoeae. The course of treatment was evaluable in 155 cases (59 men, 96 women). Bacteriologic eradication was evident in 97% (105 out of 108) of the patients treated with cefixime and in 100% (47 out of 47) of the patients treated with ceftriaxone. N. gonorrhoeae was eliminated at 98% (143 out of 146) and 100% (72 out of 72) of the infection sites in the respective treatment groups. Of the 187 isolates, 8 were penicillinase-producing (PPNG) and 20 had high-level tetracycline resistance (TRNG). The cefixime and ceftriaxone MIC90 for all 187 study isolates was 0.008 micrograms/ml. The adverse clinical experiences reported by the patients treated with cefixime (10%) were self-limiting; no adverse experiences occurred in the patients treated with ceftriaxone. Cefixime was as well tolerated and efficacious as ceftriaxone in the treatment of the patients with uncomplicated N. gonorrhoeae urethritis or cervicitis reported here.
进行了一项随机试验，比较头孢克肟（单次口服400毫克或800毫克）和头孢曲松（单次肌内注射250毫克）治疗单纯性淋病奈瑟菌尿道炎或宫颈炎的疗效和安全性。在75名男性和150名女性筛查对象中，187人淋病奈瑟菌培养结果呈阳性。155例（59名男性，96名女性）患者的治疗过程可评估。接受头孢克肟治疗的患者中97%（108例中的105例）细菌学根除明显，接受头孢曲松治疗的患者中100%（47例中的47例）细菌学根除明显。在各自治疗组中，淋病奈瑟菌在98%（146个感染部位中的143个）和100%（72个感染部位中的72个）的感染部位被清除。在187株分离菌株中，8株产青霉素酶（PPNG），20株对四环素高度耐药（TRNG）。所有187株研究分离菌株的头孢克肟和头孢曲松MIC90均为0.008微克/毫升。接受头孢克肟治疗的患者报告的不良临床经历（10%）为自限性；接受头孢曲松治疗的患者未出现不良经历。本文报道，在治疗单纯性淋病奈瑟菌尿道炎或宫颈炎患者时，头孢克肟的耐受性和疗效与头孢曲松相当。
