Van der Ploeg L H, Gottesdiener K, Lee M G
Department of Genetics and Molecular Biology, Merck Research Laboratories, Rahway, NJ 07065.
Trends Genet. 1992 Dec;8(12):452-7. doi: 10.1016/0168-9525(92)90330-7.
African trypanosomes evade the humoral immune response by periodically changing the antigenic identity of their variant cell-surface glycoprotein (VSG) coat. Antigenic variation relies on DNA rearrangement events that can translocate a silent VSG gene to a telomerically located VSG gene expression site. Antigenic switches can also be brought about by the differential transcriptional control of the expression sites, only one of which is transcribed at any time.
非洲锥虫通过周期性改变其可变细胞表面糖蛋白（VSG）外衣的抗原特性来逃避体液免疫反应。抗原变异依赖于DNA重排事件，这些事件可将沉默的VSG基因转运至位于端粒的VSG基因表达位点。抗原转换也可由表达位点的差异转录控制引起，在任何时候只有一个表达位点会被转录。
