Azogui G, Ben-Shlomo I, Zohar S, Kook A, Presser S, Aviram M
Department of Obstetrics and Gynecology, Rebecca Sieff Hospital, Safed, Israel.
Gynecol Endocrinol. 1992 Dec;6(4):253-7. doi: 10.3109/09513599209024987.
This study aimed to examine the relation between sex steroid hormone fluctuations during the menstrual cycle and serum lipoproteins and their constituents. Serum was obtained in the early follicular, preovulatory, and midluteal phases from 18 young women. Ovulation was confirmed by estrogen and progesterone assays. High density lipoprotein cholesterol (HDL-C) was found to increase by 16% in the preovulatory phase, in comparison to the early follicular phase. Serum apolipoprotein-AI (Apo-AI) was elevated in the preovulatory and mid-luteal phases (14% and 19%, respectively) in comparison to the early follicular phase. Total cholesterol, triglycerides, very low, and low density lipoprotein-cholesterol (VLDL-C and LDL-C) and apolipoprotein-B (Apo-B) serum levels did not change throughout the cycle. In the mid-luteal phase, the Apo-AI/HDL-C ratio was higher than in the other two phases, suggesting altered HDL composition during this phase. These results suggest that endogenous progesterone, unlike some synthetic progestogens, does not negate the beneficial effect of estrogen on serum lipoproteins.
本研究旨在探讨月经周期中甾体激素波动与血清脂蛋白及其成分之间的关系。从18名年轻女性的卵泡早期、排卵前期和黄体中期采集血清。通过雌激素和孕激素检测确认排卵情况。结果发现，与卵泡早期相比，排卵前期高密度脂蛋白胆固醇（HDL-C）升高了16%。与卵泡早期相比，排卵前期和黄体中期血清载脂蛋白-AI（Apo-AI）分别升高了14%和19%。总胆固醇、甘油三酯、极低密度脂蛋白胆固醇和低密度脂蛋白胆固醇（VLDL-C和LDL-C）以及血清载脂蛋白-B（Apo-B）水平在整个周期中均无变化。在黄体中期，Apo-AI/HDL-C比值高于其他两个阶段，提示该阶段HDL成分发生改变。这些结果表明，内源性孕激素与某些合成孕激素不同，不会抵消雌激素对血清脂蛋白的有益作用。
