Tanaka H, Furukawa Y, Fukunaga K, Fukunaga M
Department of Urology, Kawasaki Medical School, Okayama, Japan.
Adv Exp Med Biol. 1992;324:217-31. doi: 10.1007/978-1-4615-3398-6_25.
Patients with prostate cancer frequently have osseous metastases which are qualitatively assessed with bone scannings. We have studied the quantitative evaluation of skeletal diseases by measuring bone mineral density (BMD) in the lumbar vertebrae and radius. Forty-four patients with prostate cancer, nine with non-prostatic urogenital cancer and 90 controls were entered in this study. Among the patients with prostate cancer, the values of BMD in the lumbar vertebrae were significantly higher in patients with osseous metastasis than in those without metastasis, whereas the values of BMD in the radius were insignificantly different. Most of the patients with high levels of BMD in the lumbar vertebrae had osseous metastatic disease with no relationship between BMD in the lumbar vertebrae and the radius. The values of BMD in the lumbar vertebrae where hot spot scans were observed were related to X-ray findings. The alterations of BMD levels in the lumbar vertebrae were quantitatively evaluable as responses to androgen deprivation therapy. Measurement of BMD is useful for the accurate diagnosis of osteosclerotic lesions. BMD measurements of the lumbar vertebrae compared with those in the radius were variable in individuals.
前列腺癌患者常发生骨转移，可通过骨扫描进行定性评估。我们通过测量腰椎和桡骨的骨密度（BMD）来研究骨骼疾病的定量评估。本研究纳入了44例前列腺癌患者、9例非前列腺泌尿生殖系统癌症患者和90例对照者。在前列腺癌患者中，发生骨转移的患者腰椎骨密度值显著高于未发生转移的患者，而桡骨骨密度值差异不显著。大多数腰椎骨密度高的患者患有骨转移疾病，腰椎骨密度与桡骨骨密度之间无相关性。观察到热点扫描的腰椎骨密度值与X线表现相关。腰椎骨密度水平的变化可作为对雄激素剥夺治疗反应的定量评估指标。骨密度测量有助于准确诊断骨硬化性病变。个体腰椎与桡骨的骨密度测量结果存在差异。
