Parker G C, Winn P
Department of Psychology, University of St Andrews, Scotland, UK.
Neuroreport. 1992 Dec;3(12):1105-8. doi: 10.1097/00001756-199212000-00018.
Microinjection of cholinergic agonists into the anterior substantia nigra increases behaviours for which there is a pre-existing tendency and a low current rate. Rats received microinjections of carbachol, nicotine or a combination of both into the anterior substantia nigra. Carbachol and nicotine both stimulated consumption of palatable food in a dose-dependent manner (F(3,24) = 3.99, p < 0.02 and F(3,33) = 7.07, p < 0.01 respectively). Addition of carbachol to each dose of nicotine caused a significant increase in feeding compared with nicotine alone (F(1,23) = 7.01, p < 0.015). This suggests muscarinic or nicotinic cholinergic stimulation of the anterior substantia nigra can have behaviourally similar effects and, at the doses used here, the effects of nicotinic and muscarinic stimulation are additive.
将胆碱能激动剂微量注射到黑质前部会增加已有倾向且当前发生率较低的行为。大鼠接受了向黑质前部微量注射卡巴胆碱、尼古丁或两者的组合。卡巴胆碱和尼古丁均以剂量依赖性方式刺激美味食物的消耗（分别为F(3,24) = 3.99，p < 0.02和F(3,33) = 7.07，p < 0.01）。与单独使用尼古丁相比，在每剂尼古丁中添加卡巴胆碱会导致进食显著增加（F(1,23) = 7.01，p < 0.015）。这表明黑质前部的毒蕈碱能或烟碱能胆碱能刺激可产生行为上相似的效应，并且在此处使用的剂量下，烟碱能和毒蕈碱能刺激的效应是相加的。
