人类甲状腺球蛋白基因的5'区域包含Alu家族的成员。
The 5' region of the human thyroglobulin gene contains members of the Alu family.
作者信息
Targovnik H, Paz C, Corach D, Christophe D
机构信息
Laboratorio de Biologia Molecular, Hospital de Clinicas José de San Martin, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Argentina.
出版信息
Thyroid. 1992 Winter;2(4):321-4. doi: 10.1089/thy.1992.2.321.
Repeated sequences were identified in the 5' region of the human Tg gene in introns 4, 5, 10, and 11. Another repeated cluster was located in the 5' flanking sequences, approximately 6 Kb upstream from the first exon. The nucleotide sequence analysis indicated that these repeated sequences are members of the Alu family. The homology between the sequences of the intron 4 and the Alu consensus was 86%. The Alu member studied was oriented in the direction of transcription of the Tg.
在人Tg基因的5'区域的内含子4、5、10和11中鉴定出重复序列。另一个重复簇位于5'侧翼序列中，距离第一个外显子约6 Kb上游。核苷酸序列分析表明，这些重复序列是Alu家族的成员。内含子4序列与Alu共有序列之间的同源性为86%。所研究的Alu成员的方向与Tg的转录方向一致。
Zotero 插件