[干扰素作为支气管哮喘患者的支气管痉挛因子]
[Interferon as a bronchospastic factor in patients with bronchial asthma].
作者信息
Krasnowska M, Małolepszy J, Liebhart E
机构信息
Katedry i Kliniki Chorób Wewnetrznych i Alergologii AM we Wrocławiu.
出版信息
Pneumonol Alergol Pol. 1992;60(7-8):22-5.
PMID:1493514
Abstract
Twenty three asthmatics were examined during the symptoms free period. Each subject inhaled aerolised human interferon alpha (Hu IFN-alpha, Le) in increasing doses 4000 and 8000 units. IFN inhalation provoked significant decline in FEV1 (by 9.9% after the 1st dose and 6.6% after the 2nd dose on average). This results indicate that inhaled interferon induces bronchospastic reactions in asthmatics.
摘要
在无症状期对23名哮喘患者进行了检查。每位受试者吸入递增剂量（4000和8000单位）的雾化人α干扰素（Hu IFN-α，Le）。吸入干扰素导致第一秒用力呼气容积（FEV1）显著下降（平均第一剂后下降9.9%，第二剂后下降6.6%）。这些结果表明，吸入干扰素会在哮喘患者中引发支气管痉挛反应。
Zotero 插件