Groome L J, Singh K P, Burgard S L, Neely C L, Bartolucci A A
Department of Obstetrics and Gynecology, University of Arkansas for Medical Sciences, Little Rock 72205.
Early Hum Dev. 1992 Sep;30(2):93-9. doi: 10.1016/0378-3782(92)90137-6.
The purpose of this study was to compare two different methods for assessing fetal heart rate (FHR)--fetal eye movement (FEM) synchronization: (1) periods of high (HV) and low (LV) variability in the FHR and the presence (EM) and absence (NEM) of FEM were determined by visual inspection and the degree of association between FHR and FEM was assessed in terms of the fraction of study time for which no periods of LV-NEM and HV-EM could be identified; and (2) the maximum cross-correlation coefficient (rmax) and the lag at rmax (Lmax) were determined by direct computer analysis of FHR and FEM data for each fetus. Twenty normal human fetuses between 38 and 40 weeks of gestation were examined for a total of 2051 min (mean 103 min, range 72-150 min). In general, the state HV-EM was observed approximately twice as often as was the state LV-NEM; neither of these two states could be identified during 12.4% of the study time. The coefficient rmax was calculated assuming a sliding 3-min moving window, using either the average FHR (mean 0.53, range 0.31-0.85) or the variability in the FHR (mean 0.52, range 0.18-0.77). No relationship was found between rmax and Lmax calculated using the mean FHR and the fraction of time for which no state could be identified (P = 0.995). When the cross-correlation analysis was performed using FHR variability, a statistically significant relationship was found between the periods of no coincidence (of states LV-NEM and HV-EM) and rmax and Lmax (r2 = 0.32; P = 0.04).(ABSTRACT TRUNCATED AT 250 WORDS)
本研究的目的是比较两种评估胎儿心率（FHR）的不同方法——胎儿眼动（FEM）同步：（1）通过视觉检查确定FHR的高变异性（HV）和低变异性（LV）时期以及FEM的存在（EM）和不存在（NEM），并根据无法识别LV - NEM和HV - EM时期的研究时间比例评估FHR与FEM之间的关联程度；（2）通过对每个胎儿的FHR和FEM数据进行直接计算机分析来确定最大互相关系数（rmax）和rmax处的延迟（Lmax）。对20例妊娠38至40周的正常人类胎儿进行了检查，总时长为2051分钟（平均103分钟，范围72 - 150分钟）。一般来说，HV - EM状态的出现频率约为LV - NEM状态的两倍；在12.4%的研究时间内无法识别这两种状态中的任何一种。rmax系数是使用3分钟滑动移动窗口计算得出的，使用的是平均FHR（平均0.53，范围0.31 - 0.85）或FHR的变异性（平均0.52，范围0.18 - 0.77）。使用平均FHR计算的rmax和Lmax与无法识别任何状态的时间比例之间未发现相关性（P = 0.995）。当使用FHR变异性进行互相关分析时，在无重合时期（LV - NEM和HV - EM状态）与rmax和Lmax之间发现了统计学上的显著相关性（r2 = 0.32；P = 0.04）。（摘要截短为250字）
