Nowak D, Jörres R, Rabe K F, Lüthke M, Wiessmann J, Magnussen H
Grosshansdorf Hospital, Center for Pneumology and Thoracic Surgery, Hamburg, FRG.
Eur J Clin Pharmacol. 1992;43(6):591-5. doi: 10.1007/BF02284956.
To study the dose-response relationship of salmeterol for protection against a naturally occurring stimulus, isocapnic hyperventilation tests of cold air were done in 16 asthmatic patients. The subjects inhaled either 50 micrograms salmeterol, salbutamol 200 micrograms, or placebo in a double-blind, randomised, cross-over study. The FEV1 was measured prior to medication and the provocative ventilation (PV20) required to induce a 20% fall in FEV1 was calculated by linear interpolation from ventilation-response curves obtained 0.5, 4, 8, and 12 h after medication. Following salbutamol, the mean FEV1 were 4.11, 3.89, 3.58, and 3.55 l, with a significant difference from placebo up to 4 h. Following salmeterol, mean FEV1 values were 3.95, 4.10, 3.93, and 3.88 l, with a significant difference from placebo up to 12 h. The mean PV20FEV1 after salbutamol was 78.8, 58.5, 52.7, and 48.4 l.min-1, the 0.5 h value being significantly different from placebo. After salmeterol, the mean PV20FEV1 values were 84.6, 82.5, 67.8, and 65.8 l.min-1, with a significant difference from placebo up to 12 h. We conclude that, besides its long-lasting bronchodilating effect, salmeterol protects against hyperventilation-induced bronchoconstriction for at least 12 h.
为研究沙美特罗预防自然刺激的剂量反应关系，对16例哮喘患者进行了冷空气等碳酸通气试验。在一项双盲、随机、交叉研究中，受试者吸入50微克沙美特罗、200微克沙丁胺醇或安慰剂。在用药前测量FEV1，并根据用药后0.5、4、8和12小时获得的通气反应曲线通过线性插值计算诱导FEV1下降20%所需的激发通气量（PV20）。使用沙丁胺醇后，平均FEV1分别为4.11、3.89、3.58和3.55升，与安慰剂相比，在4小时内有显著差异。使用沙美特罗后，平均FEV1值分别为3.95、4.10、3.93和3.88升，与安慰剂相比，在12小时内有显著差异。使用沙丁胺醇后的平均PV20FEV1为78.8、58.5、52.7和48.4升·分钟-1，0.5小时的值与安慰剂有显著差异。使用沙美特罗后，平均PV20FEV1值为84.6、82.5、67.8和65.8升·分钟-1，与安慰剂相比，在12小时内有显著差异。我们得出结论，除了其持久的支气管扩张作用外，沙美特罗可预防通气过度引起的支气管收缩至少12小时。
