Gilbert I A, Fouke J M, McFadden E R
Airway Disease Center, University Hospital, Case Western Reserve University, Cleveland, Ohio 44106.
J Appl Physiol (1985). 1988 May;64(5):2167-74. doi: 10.1152/jappl.1988.64.5.2167.
To determine whether exercise and hyperventilation produce the same intrathoracic thermal events in asthmatics, we used a thermal probe to record airstream temperatures during both stimuli at multiple points within the tracheobronchial tree. From these data, the global and regionally distributed exchanges of water and heat that occurred throughout the respiratory tract were calculated. During each provocation, intra-airway temperatures fell equivalently, thereby producing similar intrathoracic water fluxes and heat transfers. Neither stimulus was associated with airway drying, and both resulted in similar distributed losses of thermal energy from the tracheobronchial tree despite small regional heat and water exchanges. The degree of airway obstruction was identical after both challenges; however, the onset of airway narrowing was earlier with hyperventilation and developed in association with more rapid rewarming. These data demonstrate that the hyperpnea of exercise and hyperventilation produce identical thermal consequences within the respiratory tract of asthmatics.
为了确定运动和过度通气在哮喘患者中是否产生相同的胸腔内热事件，我们使用热探头在气管支气管树内的多个点记录两种刺激期间的气流温度。根据这些数据，计算了整个呼吸道发生的水和热的整体及区域分布交换。在每次激发过程中，气道内温度同等下降，从而产生相似的胸腔内水通量和热传递。两种刺激均与气道干燥无关，尽管存在小范围的局部热和水交换，但两者均导致气管支气管树热能的相似分布损失。两种激发后气道阻塞程度相同；然而，过度通气时气道狭窄的发作更早，且与更快的复温相关。这些数据表明，运动性呼吸急促和过度通气在哮喘患者的呼吸道内产生相同的热效应。
