Malo J L, Cartier A, L'Archevêque J, Ghezzo H, Martin R R
Am Rev Respir Dis. 1986 Nov;134(5):990-3. doi: 10.1164/arrd.1986.134.5.990.
In 12 asthmatic subjects, we compared the bronchoconstriction obtained with 3 methods of isocapnic inhalation of cold dry air (IICDA) on 6 visits, two visits for each method: Dose-response curves (DRC), which were obtained by asking the subjects to inhale at progressively increasing degrees of ventilation (7.5, 15, 30, 60 L/min and maximal voluntary ventilation [MVV] at a fixed breathing rate); free MVV, i.e., breathing frequency not set; same degree of ventilation as the last required for DRC (VEeq). Degrees of ventilation were significantly greater with the free MVV method. The percentage fall in FEV1 obtained by VEeq method was significantly lower than the changes recorded with the DRC and the MVV methods, the 2 latter being not significantly different. We conclude that IICDA induces a cumulative bronchoconstriction by the DRC method. However, the bronchoconstriction obtained with the latter method is not significantly different from the one obtained with the free MVV method.
在12名哮喘患者中，我们比较了6次就诊时通过3种等碳酸冷干空气吸入（IICDA）方法所诱发的支气管收缩情况，每种方法进行两次就诊：剂量反应曲线（DRC），通过让受试者以逐渐增加的通气程度（7.5、15、30、60升/分钟以及在固定呼吸频率下的最大自主通气量[MVV]）进行吸入来获得；自由MVV，即呼吸频率不设定；与DRC最后所需的相同通气程度（VEeq）。自由MVV方法的通气程度显著更高。通过VEeq方法获得的FEV1下降百分比显著低于DRC和MVV方法所记录的变化，后两者无显著差异。我们得出结论，IICDA通过DRC方法诱发累积性支气管收缩。然而，通过后一种方法获得的支气管收缩与通过自由MVV方法获得的支气管收缩无显著差异。
