Caillard V, Beauté-Lafitte A, Chabaud A G, Landau I
Laboratoire de Zoologie-Vers, Muséum National d'Histoire Naturelle, Paris, France.
Exp Parasitol. 1992 Dec;75(4):449-56. doi: 10.1016/0014-4894(92)90258-c.
Antimalarial activity of arteether, a derivative of artemisinin (qinghaosu) against blood-induced infections of the highly synchronous Plasmodium vinckei petteri rodent species of malaria was evaluated in Swiss mice. A single subcurative dose of arteether of 2.2 mg/kg body weight was injected subcutaneously to mice, either during the prepatent period or during the patent infection, when different stages of the parasitic cycle were present in the blood. It was shown that rings and young trophozoites were the most susceptible stages to arteether. The drug had no effect on merozoites and little effect on mid-term trophozoites which is the stage most sensitive to chloroquine. The alcoholic solution (10% alcohol in sterile water) had an immediate effect while the oily solution (miglyol 840) was active between 3 and 21 hr after injection.
在瑞士小鼠中评估了青蒿素（青蒿素）衍生物蒿甲醚对高度同步化的恶性疟原虫彼得氏啮齿动物种血液感染的抗疟活性。在潜隐期或显性感染期，当血液中存在寄生虫周期的不同阶段时，给小鼠皮下注射单剂量2.2mg/kg体重的蒿甲醚，此剂量低于治疗剂量。结果表明，环状体和年轻滋养体是对蒿甲醚最敏感的阶段。该药物对裂殖子无作用，对中期滋养体的作用很小，而中期滋养体是对氯喹最敏感的阶段。酒精溶液（无菌水中含10%酒精）有即刻作用，而油溶液（Miglyol 840）在注射后3至21小时有活性。
