Dutta G P, Bajpai R, Vishwakarma R A
Central Drug Research Institute, Lucknow, India.
Trans R Soc Trop Med Hyg. 1989 Jan-Feb;83(1):56-7. doi: 10.1016/0035-9203(89)90704-9.
Arteether (30:70 mixture of alpha and beta epimers) used as injectable intramuscular preparation (in neutralized ground-nut oil) had curative action at 5 mg/kg x 3 d against blood-induced Plasmodium cynomolgi B infection in rhesus monkeys, while the curative dose of artemisinin (qinghaosu) oil suspension was 10 mg/kg x 7 d or 20 mg/kg x 3 d. Parasite clearance with arteether was achieved within 24 h. Neither arteether nor artemisinin exhibited any causal prophylactic or radical curative action up to dose levels of 20 mg/kg against sporozoite-induced P. cynomolgi B infection in rhesus monkeys.
蒿甲醚（α和β差向异构体的30:70混合物）作为注射用肌内制剂（用中和的花生油），在5毫克/千克×3天的剂量下对恒河猴血液感染食蟹猴疟原虫B具有治疗作用，而青蒿素（青蒿素）油悬液的治疗剂量为10毫克/千克×7天或20毫克/千克×3天。蒿甲醚在24小时内实现了寄生虫清除。在高达20毫克/千克的剂量水平下，蒿甲醚和青蒿素对恒河猴子孢子诱导的食蟹猴疟原虫B感染均未表现出任何病因性预防或根治作用。
