玻璃体内注射干扰素α-2a无毒性。
Lack of toxicity of intravitreally administered interferon alpha-2a.
作者信息
Karaçorlu M A, Peyman G A, Cruz S, Soike K F
机构信息
School of Medicine, LSU Eye Center, New Orleans 70112.
出版信息
Ophthalmic Surg. 1992 Dec;23(12):833-5.
PMID:1494441
Abstract
We investigated the toxicity of single doses of intravitreally administered interferon alpha-2a in albino rabbits. Following injection of interferon in doses of 40,000, 80,000, 160,000, 320,000, and 640,000 IU/0.1 mL, no significant histologic changes were detected by light and electron microscopy. Photopic and scotopic electroretinography showed no alteration of retinal function.
摘要
我们研究了玻璃体内单次注射干扰素α-2a对白化兔的毒性。分别以40,000、80,000、160,000、320,000和640,000国际单位/0.1毫升的剂量注射干扰素后，光镜和电镜检查均未发现明显的组织学变化。明视和暗视视网膜电图显示视网膜功能无改变。
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