CASALS J, OLITSKY P K, SABIN A B
J Exp Med. 1952 Jul;96(1):55-8. doi: 10.1084/jem.96.1.55.
CF tests with Type 2 poliomyelitis antigen (MEF1) were performed on the pre- and postinfection sera of 20 cynomolgus monkeys which developed paralytic, non-paralytic, or inapparent infection following oral administration of a Type 2 strain of virus (Y-SK). All the monkeys developed neutralizing antibody, and 17 developed CF antibody in an original serum dilution titer of 1:4 or greater. The 3 monkeys which did not develop this level of CF antibody were in a group of 7 which died within 8 days after onset of paralysis. The CF titers were as high at 2 to 6 days after onset of paralysis in the other 4 moribund or dead monkeys as in the surviving animals tested 4 weeks after the first dose of virus and the CF titers were of the same order of magnitude in the groups with paralytic, non-paralytic, or inapparent infection. The Type 2 poliomyelitis CF titers developed in monkeys as a result of infection with homotypic virus were not greater than those found in human beings infected with heterotypic Type 1 poliomyelitis strains.
用2型脊髓灰质炎抗原（MEF1）对20只食蟹猴进行补体结合试验（CF试验），这些食蟹猴在口服2型病毒株（Y-SK）后出现麻痹性、非麻痹性或隐性感染。所有猴子均产生中和抗体，17只猴子产生补体结合抗体，原始血清稀释效价为1:4或更高。未产生此水平补体结合抗体的3只猴子在一组7只猴子中，这组猴子在麻痹发作后8天内死亡。在其他4只濒死或死亡的猴子中，补体结合试验效价在麻痹发作后2至6天与首次接种病毒4周后检测的存活动物一样高，并且在麻痹性、非麻痹性或隐性感染组中补体结合试验效价处于相同数量级。食蟹猴因同型病毒感染而产生的2型脊髓灰质炎补体结合试验效价不高于感染异型1型脊髓灰质炎病毒株的人类。
