Orzincolo C, Castaldi G, Scutellari P N, Scapoli A, Ghedini M
Servizio di Radiologia, Arcispedale S. Anna, Ferrara.
Radiol Med. 1992 Dec;84(6):731-5.
Platyspondylia was observed in 14 patients affected with thalassemia major (7 males and 7 females, age range: 10-18 years) who received an intensive transfusion regimen combined with continuous chelation therapy (desferrioxamine: 50-80 mg/kg daily). Height/width ratio was decreased at all the investigated tracts--i.e., cervical and/or dorsal and/or lumbar spine. The range of height/width ratio values was 0.41-0.55 at the 5th cervical body, 0.33-0.53 at the 8th dorsal body, 0.43-0.56 at the 12th dorsal body and 0.47-0.62 at the 2nd lumbar body. The flattening of the vertebral bodies seems to be due to the depletion of hematopoetic tissue determined by the high transfusion regimen. The reduced intramedullary pressure is thought to counteract neither weight-bearing nor other biological stresses, which might ultimately provoke the thinning of vertebral bodies.
在14例重型地中海贫血患者（7例男性，7例女性，年龄范围：10 - 18岁）中观察到扁平椎，这些患者接受了强化输血方案联合持续螯合治疗（去铁胺：每日50 - 80mg/kg）。在所有研究节段，即颈椎和/或胸椎和/或腰椎，高宽比均降低。第5颈椎椎体的高宽比值范围为0.41 - 0.55，第8胸椎椎体为0.33 - 0.53，第12胸椎椎体为0.43 - 0.56，第2腰椎椎体为0.47 - 0.62。椎体扁平似乎是由于高强度输血方案导致造血组织耗竭所致。髓内压力降低被认为既不能抵消负重，也不能抵消其他生物应力，而这些应力最终可能导致椎体变薄。
