Orzincolo C, Castaldi G, Scutellari P N
Department of Radiology, St. Anna Hospital, Ferrara, Italy.
Eur J Radiol. 1994 May;18(2):129-33. doi: 10.1016/0720-048x(94)90280-1.
Flattening of the vertebral bodies with a platyspondyly appearance is described in 14 patients selected for evaluation of short stature from 106 patients affected by thalassemia major, who received an intensive transfusion regimen combined with continuous chelation therapy. The vertebral body height/width ratio was decreased at the level of all the investigated tracts, namely, cervical and/or dorsal and/or lumbar. The flattening of the vertebral bodies may be due to suppression of intramedullary hematopoiesis by a high transfusion regimen. The reduced intravertebral pressure due to disturbed hemopoiesis could cause weight-bearing and other biological stresses to provoke a reduction in vertebral body height.
在106例重型地中海贫血患者中，选取14例因身材矮小接受评估的患者，这些患者接受强化输血方案并联合持续螯合治疗。在所有研究节段，即颈椎和/或胸椎和/或腰椎水平，椎体高度/宽度比均降低。椎体扁平可能是由于高输血方案抑制了骨髓造血。造血紊乱导致椎体内压力降低，可能使负重及其他生物应力促使椎体高度降低。
